The Single Best Strategy To Use For ceesdekker

The Single Best Strategy To Use For ceesdekker

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‘The second is nanopores, that is our oldest line of analysis and which has now led to DNA sequencers depending on nanopores. We pull particular person DNA strands via a nanopore and might then read through off the nucleotide sequence. Really just lately, we even managed to read through out an individual protein for The very first time utilizing this technique. But this line of research is don't just about producing instruments, but in addition about actual biological concerns.

Human Rad51 filaments on double- and single-stranded DNA: correlating standard and irregular sorts with recombination functionality.

Multicolor imaging with the bacterial nucleoid and cell division proteins with blue, orange, and close to-infrared fluorescent proteins

Due to the fact 2000, Dekker has shifted the primary emphasis of his do the job in the direction of biophysics where he scientific studies the Houses of one biomolecules and cells using the resources of nanotechnology. This modification of industry was driven by his fascination for your impressive performing of Organic molecular structures, along with with the extensive-term viewpoint a large number of attention-grabbing discoveries can be anticipated In this particular subject.[five] Present-day strains of study https://www.ceesdekker.net in his biophysics group are inside the regions of:[6]

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Electrical transportation in monolayers of phthalocyanine molecular wires and AFM imaging of an individual wire bridging two electrodes

‘At the beginning we looked at biological devices with a Bodily watch and acted on The premise from the equipment we realized. It took a number of years prior to we commenced Doing the job more on the large Organic challenges. I then started to contact it nanobiology, a phrase that didn't exist at enough time.

Studying DNA loop extrusion by SMC proteins for chromosome architecture with solitary-molecule assays.

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Quite neat, but that wasn’t actually where by my interest lay. I wished to pioneer And that i had the feeling which was no longer achievable, since the most interesting basic insights had now been uncovered. But my area had formulated many fascinating new instruments to evaluate individual molecules. I decided that I planned to utilize this to biology, to have a look at it from a physical perspective.’

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2013, managed shaping of Reside bacterial cells into arbitrary styles; and discovery of spontaneous fluctuations inside the handedness of histone tetrasomes